Heart Disease vs Molecular Hydrogen

1. Hydrogen can potentially improve cardiac function

• Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways
• Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
• Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic post conditioning in isolated rat hearts
• Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats.

2. Hydrogen may improve the function of weakened or damaged left and right ventricles of the heart.

• Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways
• Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects
• Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model
• Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.

3. Protects heart muscle cells during ischemia, or lack of blood and oxygen.

• Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury
• Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.
• Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart.
• H2 has demonstrated the ability to reduce heart infarction size. Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.

4. Hydrogen may significantly reduce cardiac hypertrophy and cardiac fibrosis

• Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways
• Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice
• Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice

5. H2 may play an important role in improving atherosclerosis.

Primary cause of heart disease:
• Atherosclerosis
• Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
• Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial
• Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model
• Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice

6. Molecular hydrogen has the potential to decrease high blood pressure or has a normalizing effect to blood pressure. This study supports a strong, significant, and independent association of elevated blood pressure with CVD mortality risk.

• High blood pressure and cardiovascular disease mortality risk among U.S. adults: the third National Health and Nutrition Examination Survey mortality follow-up study. a
• Blood pressure and coronary heart disease: a review of the evidence. b
• The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance
• Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases
• Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation
• Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats

7. H2 has demonstrated the ability to increase HDL, or healthy cholesterol, and decrease LDL, which is bad cholesterol.

• Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial
• Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.
• Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study
• High-density lipoprotein and atherosclerosis: the role of antioxidant activity

8. H2 has the potential to protect the body from the damage of high glucose levels and reduce blood sugar/glucose levels.

• Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding
• Glucose: a continuous risk factor for cardiovascular disease.
• Hyperglycemia and cardiovascular disease
• Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome
• Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells
• Are the effects of a -glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?
• Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

9. Hydrogen has the potential to protect vascular endothelial cells and maintains blood vessel function.

• Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function

10. Hydrogen has therapeutic potential for Cardiac arrest

• Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
• The Significant Potential of Hydrogen Therapy

Prevention

• Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.
• Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function
• Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.
• Are the effects of a -glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?